Setting the moral and ethical debate aside, and going on a stricly constitutional basis, there was no justfification for the SCOTUS ruling on Roe v Wade in 73. As I've mentioned before,  even RBG thought it was a bad ruling in spite of her Pro-Life stance. There is no provision in the constitution to support it and the 10th clearly makes it a state issue. 

But, there is no doubt in my mind that this will have an impact on the mid terms this year.  It will have no real impact on the republican base, who largely supprt the recent ruling, or the dem base, who no doubt oppose it. The independents OTOH, who essentially decide elections?  That's the wild card.  How many will change their minds?

I guess it comes down to how many value the "right" to abortion over economics, border security, etc.

I suspect that it will not be a significant portion, but we'll know more in November.